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HomoloGene:8516. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   FOXP3,  H.sapiens
forkhead box P3
431 aa
   FOXP3,  M.mulatta
forkhead box P3
431 aa
   FOXP3,  C.lupus
forkhead box P3
430 aa
   FOXP3,  B.taurus
forkhead box P3
431 aa
   Foxp3,  M.musculus
forkhead box P3
429 aa
   Foxp3,  R.norvegicus
forkhead box P3
429 aa
   foxp3,  X.tropicalis
forkhead box P3
439 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Diabetes mellitus, type I, susceptibility to.
Immunodysregulation, polyendocrinopathy, and enteropathy, X-linked.

Articles associated with genes and sequences of this homology group.

B cells are critical for autoimmune pathology in Scurfy mice.
Aschermann S, et al. Proc Natl Acad Sci U S A 110, 19042-7 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FH (cl00061)
  Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Foxp3 includes H.sapiens FOXP3 and R.norvegicus Foxp3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 12 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)




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