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HomoloGene:21385. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   WWP1,  H.sapiens
WW domain containing E3 ubiquitin protein ligase 1
922 aa
   WWP1,  P.troglodytes
WW domain containing E3 ubiquitin protein ligase 1
922 aa
   WWP1,  M.mulatta
WW domain containing E3 ubiquitin protein ligase 1
922 aa
   WWP1,  C.lupus
WW domain containing E3 ubiquitin protein ligase 1
922 aa
   WWP1,  B.taurus
WW domain containing E3 ubiquitin protein ligase 1
921 aa
   Wwp1,  M.musculus
WW domain containing E3 ubiquitin protein ligase 1
918 aa
   Wwp1,  R.norvegicus
WW domain containing E3 ubiquitin protein ligase 1
918 aa
   WWP1,  G.gallus
WW domain containing E3 ubiquitin protein ligase 1
922 aa
   wwp1,  X.tropicalis
WW domain containing E3 ubiquitin protein ligase 1
914 aa
   Su(dx),  D.melanogaster
Suppressor of deltex
949 aa
   AgaP_AGAP009074,  A.gambiae
891 aa
   wwp-1,  C.elegans
794 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

WWP1 gene is a potential molecular target of human oral cancer.
Lin JH, et al. Oral Surg Oral Med Oral Pathol Oral Radiol 116, 221-31 (2013).
WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.
Zhi X & Chen C. Cell Mol Life Sci 69, 1425-34 (2012).
Exclusion of WWP1 mutations in a cohort of dystroglycanopathy patients.
Godfrey C, et al. Muscle Nerve 44, 388-92 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HECTc (smart00119)
  Domain Homologous to E6-AP Carboxyl Terminus with.
HECTc (cl00077)
  HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
WW (cl00157)
  Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.
C2 (cl14603)
  C2 domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Wwp1 includes H.sapiens WWP1 and R.norvegicus Wwp1.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (12 transcripts, 10 species)
Amphibia - amphibians (3 transcripts, 2 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Insecta - insects (8 transcripts, 7 species)

Chromadorea - nematodes (2 transcripts, 2 species)

Anthozoa - anthozoans (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)




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