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HomoloGene:21195. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IDH1,  H.sapiens
isocitrate dehydrogenase 1 (NADP+), soluble
    NP_005887.2
414 aa
   IDH1,  P.troglodytes
isocitrate dehydrogenase 1 (NADP+), soluble
    XP_001141655.1
414 aa
   IDH1,  M.mulatta
isocitrate dehydrogenase 1 (NADP+), soluble
    XP_001107934.1
414 aa
   IDH1,  C.lupus
isocitrate dehydrogenase 1 (NADP+), soluble
    XP_536047.2
414 aa
   IDH1,  B.taurus
isocitrate dehydrogenase 1 (NADP+), soluble
    NP_851355.2
414 aa
   Idh1,  M.musculus
isocitrate dehydrogenase 1 (NADP+), soluble
    NP_034627.3
414 aa
   Idh1,  R.norvegicus
isocitrate dehydrogenase 1 (NADP+), soluble
    NP_113698.1
414 aa
   IDH1,  G.gallus
isocitrate dehydrogenase 1 (NADP+), soluble
    XP_004942738.1
444 aa
   idh1,  D.rerio
isocitrate dehydrogenase 1 (NADP+), soluble
    NP_958907.1
429 aa
   Idh,  D.melanogaster
Isocitrate dehydrogenase
    NP_652044.1
469 aa
   AgaP_AGAP006660,  A.gambiae
AgaP_AGAP006660
    XP_316694.4
413 aa
   idh-1,  C.elegans
idh-1
    NP_001255392.1
435 aa
   IDP1,  S.cerevisiae
IDP1
    NP_010217.1
428 aa
   KLLA0B03355g,  K.lactis
KLLA0B03355g
    XP_451683.1
429 aa
   AGOS_AER061C,  E.gossypii
AGOS_AER061C
    NP_984921.1
425 aa
   idp1,  S.pombe
idp1
    NP_594105.2
439 aa
   MGG_07268,  M.oryzae
MGG_07268
    XP_003715491.1
450 aa
   NCU03857,  N.crassa
NCU03857
    XP_955850.1
462 aa
   cICDH,  A.thaliana
cICDH
    NP_176768.1
410 aa
   Os01g0654500,  O.sativa
Os01g0654500
    NP_001043749.1
412 aa
   Os05g0573200,  O.sativa
Os05g0573200
    NP_001056381.1
412 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Non-invasive in vivo assessment of IDH1 mutational status in glioma.
Chaumeil MM, et al. Nat Commun 4, 2429 (2013).
[Mutation of isocitrate dehydrogenase gene in Chinese patients with glioma].
Pan Y, et al. Zhonghua Bing Li Xue Za Zhi 42, 292-8 (2013).
Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.
Hodges TR, et al. J Neurosurg 118, 1176-80 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Iso_dh (cl00445)
  Isocitrate/isopropylmalate dehydrogenase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Idh1 includes H.sapiens IDH1 and R.norvegicus Idh1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (78 transcripts, 35 species)
Liliopsida - monocots (16 transcripts, 9 species)
Coniferopsida - conifers (8 transcripts, 3 species)
Isoetopsida - club-mosses (4 transcripts, 1 species)
Bryopsida - mosses (3 transcripts, 1 species)

Chordata
Mammalia - mammals (19 transcripts, 16 species)
Actinopterygii - bony fishes (16 transcripts, 12 species)
Ascidiacea - tunicates (5 transcripts, 3 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (16 transcripts, 13 species)
Arachnida - arachnids (3 transcripts, 2 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (7 transcripts, 2 species)

Apicomplexa
Coccidia - apicomplexans (3 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (2 transcripts, 1 species)
Pythiales - oomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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