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HomoloGene:81825. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   AGO2,  H.sapiens
argonaute RISC catalytic component 2
    NP_036286.2
859 aa
   EIF2C2,  P.troglodytes
eukaryotic translation initiation factor 2C, 2
    XP_001142838.1
813 aa
   LOC711873,  M.mulatta
protein argonaute-2-like
    XP_001100725.2
1333 aa
   AGO2,  C.lupus
argonaute RISC catalytic component 2
    XP_005628049.1
813 aa
   EIF2C2,  B.taurus
eukaryotic translation initiation factor 2C, 2
    NP_991363.1
860 aa
   Ago2,  M.musculus
argonaute RISC catalytic subunit 2
    NP_694818.3
860 aa
   Ago2,  R.norvegicus
argonaute RISC catalytic component 2
    NP_067608.1
863 aa
   LOC100858102,  G.gallus
protein argonaute-2-like
    XP_004940122.1
864 aa
   ago2,  X.tropicalis
argonaute RISC catalytic component 2
    NP_001004877.1
871 aa
   LOC570630,  D.rerio
protein argonaute-2-like
    XP_699226.2
873 aa
   AGO1,  D.melanogaster
Argonaute-1
    NP_001246314.1
984 aa
   AgaP_AGAP011717,  A.gambiae
AgaP_AGAP011717
    XP_320795.4
981 aa
   alg-2,  C.elegans
alg-2
    NP_871992.1
910 aa
   alg-1,  C.elegans
alg-1
    NP_001257238.1
1002 aa
   AGO5,  A.thaliana
AGO5
    NP_850110.1
997 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Argonaute2 regulates the pancreatic β-cell secretome.
Tattikota SG, et al. Mol Cell Proteomics 12, 1214-25 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF1785 (pfam08699)
  Domain of unknown function (DUF1785).
DUF1785 (pfam08699)
  Domain of unknown function (DUF1785).
PAZ (cl00301)
  PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a ...
Piwi-like (cl00628)
  Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ago2 includes H.sapiens AGO2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (63 transcripts, 34 species)
Liliopsida - monocots (36 transcripts, 8 species)
Bryopsida - mosses (5 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Isoetopsida - club-mosses (2 transcripts, 1 species)

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (7 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Ascomycota
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

 

 

 

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