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HomoloGene:379. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PCSK1,  H.sapiens
proprotein convertase subtilisin/kexin type 1
    NP_000430.3
753 aa
   PCSK1,  P.troglodytes
proprotein convertase subtilisin/kexin type 1
    XP_001134900.1
753 aa
   PCSK1,  M.mulatta
proprotein convertase subtilisin/kexin type 1
    XP_002804496.1
706 aa
   PCSK1,  C.lupus
proprotein convertase subtilisin/kexin type 1
    XP_848637.1
753 aa
   PCSK1,  B.taurus
proprotein convertase subtilisin/kexin type 1
    NP_776837.1
753 aa
   Pcsk1,  M.musculus
proprotein convertase subtilisin/kexin type 1
    NP_038656.1
753 aa
   PCSK1,  G.gallus
proprotein convertase subtilisin/kexin type 1
    XP_003643108.1
748 aa
   pcsk1,  X.tropicalis
proprotein convertase subtilisin/kexin type 1
    XP_004910515.1
852 aa
   pcsk1,  D.rerio
proprotein convertase subtilisin/kexin type 1
    NP_001131134.1
755 aa
   bli-4,  C.elegans
bli-4
    NP_001021543.1
942 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obestiy with impaired prohormone processing.



Publications
Articles associated with genes and sequences of this homology group.

Severe obesity and diabetes insipidus in a patient with PCSK1 deficiency.
Frank GR, et al. Mol Genet Metab 110, 191-4 (2013).
Hysteretic behavior of proprotein convertase 1/3 (PC1/3).
Icimoto MY, et al. PLoS One 6, e24545 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Proho_convert (pfam12177)
  Prohormone convertase enzyme.
P_proprotein (pfam01483)
  Proprotein convertase P-domain.
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
P_proprotein (pfam01483)
  Proprotein convertase P-domain.
Peptidases_S8_S53 (cl10459)
  Peptidase domain in the S8 and S53 families.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pcsk1 includes H.sapiens PCSK1 and R.norvegicus Pcsk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Aves - birds (3 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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