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HomoloGene:56556. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SIRT1,  H.sapiens
sirtuin 1
    NP_036370.2
747 aa
   SIRT1,  P.troglodytes
sirtuin 1
    XP_003312628.1
751 aa
   SIRT1,  M.mulatta
sirtuin 1
    XP_001087854.2
713 aa
   SIRT1,  C.lupus
sirtuin 1
    XP_546130.2
745 aa
   SIRT1,  B.taurus
sirtuin 1
    NP_001179909.1
734 aa
   Sirt1,  M.musculus
sirtuin 1
    NP_062786.1
737 aa
   Sirt1,  R.norvegicus
sirtuin 1
    XP_006256208.1
712 aa
   SIRT1,  G.gallus
sirtuin 1
    NP_001004767.1
756 aa
   sirt1,  X.tropicalis
sirtuin 1
    NP_001136381.1
659 aa
   sirt1,  D.rerio
sirtuin (silent mating type information regulation 2 homolog) 1
    XP_005173091.1
695 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

SIRT1 in neurodevelopment and brain senescence.
Herskovits AZ & Guarente L. Neuron 81, 471-83 (2014).
Novel role of silent information regulator 1 in myocardial ischemia.
Yang Y, et al. Circulation 128, 2232-40 (2013).
New role of silent information regulator 1 in cerebral ischemia.
Yang Y, et al. Neurobiol Aging 34, 2879-88 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SIR2 (cl00195)
  SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sirt1 includes H.sapiens SIRT1 and R.norvegicus Sirt1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 7 species)
Mammalia - mammals (10 transcripts, 9 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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