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HomoloGene:37914. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   RUNX3,  H.sapiens
runt-related transcription factor 3
429 aa
   RUNX3,  P.troglodytes
runt-related transcription factor 3
428 aa
   LOC487366,  C.lupus
collagen alpha-1(III) chain-like
932 aa
   RUNX3,  B.taurus
runt-related transcription factor 3
420 aa
   Runx3,  M.musculus
runt related transcription factor 3
423 aa
   Runx3,  R.norvegicus
runt-related transcription factor 3
409 aa
   RUNX3,  G.gallus
runt-related transcription factor 3
417 aa
   runx3,  X.tropicalis
runt-related transcription factor 3
396 aa
   runx3,  D.rerio
runt-related transcription factor 3
424 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Demethylation of RUNX3 by vincristine in colorectal adenocarcinoma cells.
Moon JW, et al. Anticancer Res 34, 133-40 (2014).
RUNX3 is a prognostic marker and potential therapeutic target in human breast cancer.
Bai J, et al. J Cancer Res Clin Oncol 139, 1813-23 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Runt (pfam00853)
  Runt domain.
RunxI (pfam08504)
  Runx inhibition domain.
Runt (pfam00853)
  Runt domain.
RunxI (pfam08504)
  Runx inhibition domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Runx3 includes H.sapiens RUNX3 and R.norvegicus Runx3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (1 transcript, 1 species)




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