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HomoloGene:41. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BRCA2,  H.sapiens
breast cancer 2, early onset
    NP_000050.2
3418 aa
   BRCA2,  P.troglodytes
breast cancer 2, early onset
    XP_509619.2
3418 aa
   BRCA2,  M.mulatta
breast cancer 2, early onset
    XP_001118184.2
3364 aa
   BRCA2,  C.lupus
breast cancer 2, early onset
    NP_001006654.2
3446 aa
   BRCA2,  B.taurus
breast cancer 2, early onset
    XP_002691853.1
3427 aa
   Brca2,  M.musculus
breast cancer 2
    NP_033895.2
3329 aa
   Brca2,  R.norvegicus
breast cancer 2, early onset
    NP_113730.2
3343 aa
   BRCA2,  G.gallus
breast cancer 2, early onset
    NP_989607.2
3397 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer, male, susceptibility to.
Medulloblastoma.
Prostate cancer.
Wilms tumor.
Pancreatic cancer.
Breast cancer 2, early onset.
Fanconi anemia, complementation group D1.



Publications
Articles associated with genes and sequences of this homology group.

Tumour diploidy and survival in breast cancer patients with BRCA2 mutations.
Tryggvadottir L, et al. Breast Cancer Res Treat 140, 375-84 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCA-2_helical (pfam09169)
  BRCA2, helical.
BRCA2 (pfam00634)
  BRCA2 repeat.
RPA_2b-aaRSs_OBF_like (cl09930)
  Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Brca2 includes H.sapiens BRCA2 and R.norvegicus Brca2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

 

 

 

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