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HomoloGene:11173. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CBFB,  H.sapiens
core-binding factor, beta subunit
    NP_074036.1
187 aa
   CBFB,  M.mulatta
core-binding factor, beta subunit
    XP_001086629.1
187 aa
   CBFB,  C.lupus
core-binding factor, beta subunit
    XP_005620950.1
167 aa
   CBFB,  B.taurus
core-binding factor, beta subunit
    NP_001178364.1
182 aa
   Cbfb,  M.musculus
core binding factor beta
    NP_071704.3
187 aa
   Cbfb,  R.norvegicus
core-binding factor, beta subunit
    NP_001013209.1
182 aa
   CBFB,  G.gallus
core-binding factor, beta subunit
    NP_989901.2
182 aa
   cbfb,  X.tropicalis
core-binding factor, beta subunit
    XP_002937211.2
185 aa
   cbfb,  D.rerio
core-binding factor, beta subunit
    NP_954679.1
187 aa
   Bgb,  D.melanogaster
Big brother
    NP_001261271.1
253 aa
   AgaP_AGAP000317,  A.gambiae
AgaP_AGAP000317
    XP_310806.3
230 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myeloid leukemia, acute, M4Eo subtype.



Publications
Articles associated with genes and sequences of this homology group.

Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice.
Heilman SA, et al. Cancer Res 66, 11214-8 (2006).
Structure and backbone dynamics of Apo-CBFbeta in solution.
Wolf-Watz M, et al. Biochemistry 40, 11423-32 (2001).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
CBF_beta (pfam02312)
  Core binding factor beta subunit.
CBF_beta (pfam02312)
  Core binding factor beta subunit.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cbfb includes H.sapiens CBFB and R.norvegicus Cbfb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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