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HomoloGene:75345. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

TRIM5,  H.sapiens
tripartite motif containing 5
493 aa
TRIM5,  P.troglodytes
tripartite motif containing 5
493 aa
TRIM5,  M.mulatta
tripartite motif containing 5
497 aa
LOC616948,  B.taurus
tripartite motif-containing protein 5-like
498 aa
LOC516599,  B.taurus
tripartite motif containing 5-like
495 aa
Trim5,  M.musculus
tripartite motif-containing 5
497 aa
Trim12c,  M.musculus
tripartite motif-containing 12C
497 aa
Trim5,  R.norvegicus
tripartite motif-containing 5
511 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

TRIM5 alpha drives SIVsmm evolution in rhesus macaques.
Wu F, et al. PLoS Pathog 9, e1003577 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TMF_TATA_bd (pfam12325)
  TATA element modulatory factor 1 TATA binding.
BBOX (cl00034)
  B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
SPRY (cl02614)
  SPRY domain.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Trim5 includes H.sapiens TRIM5.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (11 transcripts, 9 species)




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