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HomoloGene:1849. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MYD88,  H.sapiens
myeloid differentiation primary response 88
    NP_002459.2
309 aa
   MYD88,  P.troglodytes
myeloid differentiation primary response gene (88)
    NP_001123935.1
296 aa
   MYD88,  M.mulatta
myeloid differentiation primary response gene (88)
    NP_001124153.1
296 aa
   MYD88,  C.lupus
myeloid differentiation primary response 88
    XP_534223.2
296 aa
   MYD88,  B.taurus
myeloid differentiation primary response gene (88)
    NP_001014404.1
296 aa
   Myd88,  M.musculus
myeloid differentiation primary response gene 88
    NP_034981.1
296 aa
   Myd88,  R.norvegicus
myeloid differentiation primary response 88
    NP_937763.1
296 aa
   MYD88,  G.gallus
myeloid differentiation primary response gene (88)
    NP_001026133.1
376 aa
   myd88,  X.tropicalis
myeloid differentiation primary response 88
    NP_001016837.1
283 aa
   myd88,  D.rerio
myeloid differentiation primary response gene (88)
    NP_997979.2
284 aa
   MYD,  A.gambiae
MYD
    XP_314167.4
462 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pyogenic bacterial infections, recurrent, due to MYD88 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.
Kanczkowski W, et al. Proc Natl Acad Sci U S A 110, 14801-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Death_MyD88 (cd08312)
  Death domain of Myeloid Differentation primary response protein MyD88.
TIR_2 (pfam13676)
  TIR domain.
DD_superfamily (cl14633)
  The Death Domain Superfamily of protein-protein interaction domains.
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
TIR_2 (cl17458)
  TIR domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Myd88 includes H.sapiens MYD88 and R.norvegicus Myd88.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 11 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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