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HomoloGene:55649. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LYN,  H.sapiens
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_002341.1
512 aa
   LYN,  P.troglodytes
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    XP_528143.2
512 aa
   LYN,  M.mulatta
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    XP_001087049.2
512 aa
   LYN,  C.lupus
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    XP_535078.2
512 aa
   LYN,  B.taurus
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001171211.1
512 aa
   Lyn,  M.musculus
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
    NP_001104566.1
512 aa
   Lyn,  R.norvegicus
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_110484.1
512 aa
   LYN,  G.gallus
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001006390.1
492 aa
   lyn,  X.tropicalis
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001017235.1
488 aa
   lyn,  D.rerio
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001004543.1
510 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

B cell-specific loss of Lyn kinase leads to autoimmunity.
Lamagna C, et al. J Immunol 192, 919-28 (2014).
Lyn deficiency affects B-cell maturation as well as survival.
Shahaf G, et al. Eur J Immunol 42, 511-21 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lyn includes H.sapiens LYN and R.norvegicus Lyn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 11 species)
Actinopterygii - bony fishes (13 transcripts, 6 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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