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HomoloGene:1744. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   LRP1,  H.sapiens
low density lipoprotein receptor-related protein 1
    NP_002323.2
4544 aa
   LRP1,  P.troglodytes
low density lipoprotein receptor-related protein 1
    XP_003952220.1
4419 aa
   LRP1,  C.lupus
low density lipoprotein receptor-related protein 1
    XP_538245.4
4544 aa
   LRP1,  B.taurus
low density lipoprotein receptor-related protein 1
    XP_003586126.1
4544 aa
   Lrp1,  M.musculus
low density lipoprotein receptor-related protein 1
    NP_032538.2
4545 aa
   Lrp1,  R.norvegicus
low density lipoprotein receptor-related protein 1
    NP_001123962.1
4545 aa
   LRP1,  G.gallus
low density lipoprotein receptor-related protein 1
    NP_990573.1
4543 aa
   LOC100485788,  X.tropicalis
low-density lipoprotein receptor-related protein 1-like
    XP_002939758.2
4543 aa
   LOC565797,  D.rerio
low-density lipoprotein receptor-related protein 1-like
    XP_005162276.1
4549 aa
   LRP1,  D.melanogaster
LDL receptor protein 1
    NP_788284.2
4725 aa
   AgaP_AGAP012372,  A.gambiae
AgaP_AGAP012372
    XP_320185.4
4718 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

LRP-1: a checkpoint for the extracellular matrix proteolysis.
Etique N, et al. Biomed Res Int 2013, 152163 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ldl_recept_b (cl10508)
  Low-density lipoprotein receptor repeat class B.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Ldl_recept_b (pfam00058)
  Low-density lipoprotein receptor repeat class B.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
LDLa (cl00104)
  Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lrp1 includes H.sapiens LRP1 and R.norvegicus Lrp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (22 transcripts, 7 species)
Mammalia - mammals (19 transcripts, 9 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

 

 

 

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