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HomoloGene:37325. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CCR5,  H.sapiens
chemokine (C-C motif) receptor 5 (gene/pseudogene)
    NP_001093638.1
352 aa
   CCR5,  P.troglodytes
chemokine (C-C motif) receptor 5
    NP_001009046.1
352 aa
   CCR5,  M.mulatta
chemokine (C-C motif) receptor 5
    NP_001036238.2
352 aa
   CCR5,  C.lupus
chemokine (C-C motif) receptor 5
    NP_001012342.2
352 aa
   CCR5,  B.taurus
chemokine (C-C motif) receptor 5
    NP_001011672.2
352 aa
   Ccr5,  M.musculus
chemokine (C-C motif) receptor 5
    NP_034047.2
354 aa
   Ccr5,  R.norvegicus
chemokine (C-C motif) receptor 5
    NP_446412.2
354 aa
   LOC101731980,  X.tropicalis
c-C chemokine receptor type 5-like
    XP_004915406.1
353 aa
   LOC100005081,  D.rerio
c-C chemokine receptor type 5-like
    XP_001344220.4
358 aa
   LOC100004625,  D.rerio
c-C chemokine receptor type 2-like
    XP_001343879.1
335 aa
   LOC100004988,  D.rerio
c-C chemokine receptor type 5-like
    XP_001344151.1
354 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
HIV infection, susceptibility/resistance to.
West nile virus, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Loss of CCR5 results in glucose intolerance in diet-induced obese mice.
Kennedy A, et al. Am J Physiol Endocrinol Metab 305, E897-906 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA02834 (PHA02834)
  chemokine receptor-like protein; Provisional.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).
7tm_4 (pfam13853)
  Olfactory receptor.
PHA03087 (PHA03087)
  G protein-coupled chemokine receptor-like protein; Provisional.
7tm_1 (pfam00001)
  7 transmembrane receptor (rhodopsin family).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ccr5 includes H.sapiens CCR5 and R.norvegicus Ccr5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 14 species)
Actinopterygii - bony fishes (1 transcript, 1 species)

 

 

 

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