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HomoloGene:1171. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   HIF1A,  H.sapiens
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    NP_001521.1
826 aa
   HIF1A,  P.troglodytes
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    XP_001168972.1
826 aa
   HIF1A,  M.mulatta
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    XP_001099149.1
826 aa
   HIF1A,  C.lupus
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    XP_003639249.1
823 aa
   HIF1A,  B.taurus
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    NP_776764.2
823 aa
   Hif1a,  M.musculus
hypoxia inducible factor 1, alpha subunit
    NP_034561.2
836 aa
   Hif1a,  R.norvegicus
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    NP_077335.1
823 aa
   HIF1A,  G.gallus
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    NP_989628.1
811 aa
   hif1ab,  D.rerio
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b
    NP_956527.1
533 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HIF-1a_CTAD (pfam08778)
  HIF-1 alpha C terminal transactivation domain.
HIF-1 (pfam11413)
  Hypoxia-inducible factor-1.
PAS_3 (pfam08447)
  PAS fold.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
PAS_11 (pfam14598)
  PAS domain.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Hif1a includes H.sapiens HIF1A and R.norvegicus Hif1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (26 transcripts, 16 species)
Actinopterygii - bony fishes (14 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

 

 

 

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