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HomoloGene:2971. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NFKB1,  H.sapiens
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    NP_003989.2
969 aa
   NFKB1,  P.troglodytes
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    XP_001168718.1
969 aa
   NFKB1,  M.mulatta
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    XP_002804199.1
977 aa
   NFKB1,  C.lupus
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    NP_001003344.1
972 aa
   NFKB1,  B.taurus
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    NP_001069877.1
969 aa
   Nfkb1,  M.musculus
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
    NP_032715.2
971 aa
   Nfkb1,  R.norvegicus
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    NP_001263640.1
972 aa
   NFKB1,  G.gallus
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    NP_990465.1
983 aa
   nfkb1,  X.tropicalis
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
    XP_002934805.2
956 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

NF-κB control of T cell development.
Gerondakis S, et al. Nat Immunol 15, 15-25 (2014).
Epigenetic roles of MLL oncoproteins are dependent on NF-κB.
Kuo HP, et al. Cancer Cell 24, 423-37 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Death_NFkB1_p105 (cd08797)
  Death domain of the Nuclear Factor-KappaB1 precursor protein p105.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
RHD-n (cl08275)
  N-terminal sub-domain of the Rel homology domain (RHD).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
RHD-n (cl08275)
  N-terminal sub-domain of the Rel homology domain (RHD).
DD (cl14633)
  Death Domain Superfamily of protein-protein interaction domains.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nfkb1 includes H.sapiens NFKB1 and R.norvegicus Nfkb1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 12 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 5 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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