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HomoloGene:22778. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MMEL1,  H.sapiens
membrane metallo-endopeptidase-like 1
    NP_258428.2
779 aa
   MMEL1,  P.troglodytes
membrane metallo-endopeptidase-like 1
    XP_001150860.1
781 aa
   MMEL1,  C.lupus
membrane metallo-endopeptidase-like 1
    XP_005620485.1
818 aa
   MMEL1,  B.taurus
membrane metallo-endopeptidase-like 1
    NP_001180065.1
779 aa
   Mmel1,  M.musculus
membrane metallo-endopeptidase-like 1
    NP_038811.2
766 aa
   Mmel1,  R.norvegicus
membrane metallo-endopeptidase-like 1
    NP_001101467.1
775 aa
   MMEL1,  G.gallus
membrane metallo-endopeptidase-like 1
    XP_001233077.3
773 aa
   mmel1,  X.tropicalis
membrane metallo-endopeptidase-like 1
    NP_001120567.1
745 aa
   mmel1,  D.rerio
membrane metallo-endopeptidase-like 1
    XP_689191.3
765 aa
   Nep4,  D.melanogaster
Neprilysin 4
    NP_650904.3
1040 aa
   AgaP_AGAP003106,  A.gambiae
AgaP_AGAP003106
    XP_312790.4
994 aa
   nep-2,  C.elegans
nep-2
    NP_494343.2
736 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis.
Ouimet T, et al. Biochem Biophys Res Commun 271, 565-70 (2000).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GluZincin (cl14813)
  Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mmel1 includes H.sapiens MMEL1 and R.norvegicus Mmel1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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