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HomoloGene:10771. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   FGF23,  H.sapiens
fibroblast growth factor 23
251 aa
   FGF23,  P.troglodytes
fibroblast growth factor 23
251 aa
   FGF23,  M.mulatta
fibroblast growth factor 23
251 aa
   FGF23,  C.lupus
fibroblast growth factor 23
312 aa
   FGF23,  B.taurus
fibroblast growth factor 23
245 aa
   Fgf23,  M.musculus
fibroblast growth factor 23
251 aa
   Fgf23,  R.norvegicus
fibroblast growth factor 23
251 aa
   FGF23,  G.gallus
fibroblast growth factor 23
254 aa
   fgf23.1,  X.tropicalis
fibroblast growth factor 23, gene 1
244 aa
   LOC100496800,  X.tropicalis
fibroblast growth factor 23-like
254 aa
   fgf23,  D.rerio
fibroblast growth factor 23
258 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hypophosphatemic rickets, autosomal dominant.
Tumoral calcinosis, hyperphosphatemic, familial.
calcinosis, tumoral, with hyperphosphatemia.
Osteomalacia, tumor-induced.

Articles associated with genes and sequences of this homology group.

The value of serum FGF-23 as a cardiovascular marker in HD patients.
Sany D, et al. Saudi J Kidney Dis Transpl 25, 44-52 (2014).
Calcium regulates FGF-23 expression in bone.
David V, et al. Endocrinology 154, 4469-82 (2013).
The changing face of hypophosphatemic disorders in the FGF-23 era.
Lee JY & Imel EA. Pediatr Endocrinol Rev 10 Suppl 2, 367-79 (2013).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FGF (cl00060)
  Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgf23 includes H.sapiens FGF23 and R.norvegicus Fgf23.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (4 transcripts, 4 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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