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HomoloGene:4051. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ITK,  H.sapiens
IL2-inducible T-cell kinase
    NP_005537.3
620 aa
   ITK,  P.troglodytes
IL2-inducible T-cell kinase
    XP_001136073.1
620 aa
   ITK,  M.mulatta
IL2-inducible T-cell kinase
    XP_001113468.1
620 aa
   ITK,  C.lupus
IL2-inducible T-cell kinase
    XP_546277.3
620 aa
   ITK,  B.taurus
IL2-inducible T-cell kinase
    NP_001098858.1
620 aa
   Itk,  M.musculus
IL2 inducible T cell kinase
    NP_001268894.1
625 aa
   Itk,  R.norvegicus
IL2-inducible T-cell kinase
    NP_001102295.1
626 aa
   ITK,  G.gallus
IL2-inducible T-cell kinase
    XP_414568.3
631 aa
   itk,  D.rerio
IL2-inducible T-cell kinase
    NP_571179.1
616 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Lymphoproliferative syndrome, EBV-associated, autosomal, 1.



Publications
Articles associated with genes and sequences of this homology group.

Regulation of T-cell responses and disease by tec kinase Itk.
August A & Ragin MJ. Int Rev Immunol 31, 155-65 (2012).
Itk controls the spatiotemporal organization of T cell activation.
Singleton KL, et al. Sci Signal 4, ra66 (2011).
[Research of ITK regulation on mouse spleen lymphocytes proliferation and differentiation].
Xiao ZH, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23, 269-71 (2009).
The Tec family kinase Itk exists as a folded monomer in vivo.
Qi Q & August A. J Biol Chem 284, 29882-92 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BTK (cl02465)
  BTK motif.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itk includes H.sapiens ITK and R.norvegicus Itk.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)

 

 

 

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