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HomoloGene:4051. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   ITK,  H.sapiens
IL2-inducible T-cell kinase
620 aa
   ITK,  P.troglodytes
IL2-inducible T-cell kinase
620 aa
   ITK,  M.mulatta
IL2-inducible T-cell kinase
620 aa
   ITK,  C.lupus
IL2-inducible T-cell kinase
620 aa
   ITK,  B.taurus
IL2-inducible T-cell kinase
620 aa
   Itk,  M.musculus
IL2 inducible T cell kinase
625 aa
   Itk,  R.norvegicus
IL2-inducible T-cell kinase
626 aa
   ITK,  G.gallus
IL2-inducible T-cell kinase
631 aa
   itk,  D.rerio
IL2-inducible T-cell kinase
616 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Lymphoproliferative syndrome, EBV-associated, autosomal, 1.

Articles associated with genes and sequences of this homology group.

Regulation of T-cell responses and disease by tec kinase Itk.
August A & Ragin MJ. Int Rev Immunol 31, 155-65 (2012).
Itk controls the spatiotemporal organization of T cell activation.
Singleton KL, et al. Sci Signal 4, ra66 (2011).
[Research of ITK regulation on mouse spleen lymphocytes proliferation and differentiation].
Xiao ZH, et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 23, 269-71 (2009).
The Tec family kinase Itk exists as a folded monomer in vivo.
Qi Q & August A. J Biol Chem 284, 29882-92 (2009).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BTK (cl02465)
  BTK motif.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SH3 (cl17036)
  Src Homology 3 domain superfamily.
PH-like (cl17171)
  Pleckstrin homology-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itk includes H.sapiens ITK and R.norvegicus Itk.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)




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