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HomoloGene:173. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   INS,  H.sapiens
insulin
    NP_000198.1
110 aa
   INS,  P.troglodytes
insulin
    NP_001008996.1
110 aa
   INS,  C.lupus
insulin
    NP_001123565.1
110 aa
   Ins2,  M.musculus
insulin II
    NP_032413.1
110 aa
   Ins2,  R.norvegicus
insulin 2
    NP_062003.1
110 aa
   INS,  G.gallus
insulin
    NP_990553.1
107 aa
   ins,  X.tropicalis
insulin
    NP_001093706.1
106 aa
   ins,  D.rerio
preproinsulin
    NP_571131.1
108 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
MODY, one form.
Diabetes mellitus, rare form.
Hyperproinsulinemia, familial.



Publications
Articles associated with genes and sequences of this homology group.

[The role of insulin resistace in preeclampsia].
Mladenova M, et al. Akush Ginekol (Sofiia) 52, 5-9 (2013).
Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells.
Mitchell T, et al. Am J Physiol Endocrinol Metab 305, E585-99 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IlGF_like (cl02453)
  Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ins2 includes H.sapiens INS and R.norvegicus Ins2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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