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HomoloGene:2395. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ADAM17,  H.sapiens
ADAM metallopeptidase domain 17
    NP_003174.3
824 aa
   ADAM17,  P.troglodytes
ADAM metallopeptidase domain 17
    XP_515293.2
824 aa
   ADAM17,  M.mulatta
ADAM metallopeptidase domain 17
    XP_002799185.1
711 aa
   ADAM17,  C.lupus
ADAM metallopeptidase domain 17
    XP_005630166.1
823 aa
   ADAM17,  B.taurus
ADAM metallopeptidase domain 17
    XP_002691532.1
825 aa
   Adam17,  M.musculus
a disintegrin and metallopeptidase domain 17
    NP_033745.4
827 aa
   Adam17,  R.norvegicus
ADAM metallopeptidase domain 17
    NP_064702.1
827 aa
   ADAM17,  G.gallus
ADAM metallopeptidase domain 17
    NP_001008682.1
829 aa
   adam17,  X.tropicalis
ADAM metallopeptidase domain 17
    NP_001182159.1
843 aa
   adam17a,  D.rerio
a disintegrin and metalloproteinase domain 17a
    NP_955967.1
842 aa
   adam17b,  D.rerio
a disintegrin and metallopeptidase domain 17b
    XP_689147.3
793 aa
   Tace,  D.melanogaster
Tace
    NP_733334.1
732 aa
   AgaP_AGAP002381,  A.gambiae
AgaP_AGAP002381
    XP_312572.5
759 aa
   adm-4,  C.elegans
adm-4
    NP_509318.1
686 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

TACE in perinatal mouse lung epithelial cells promotes lung saccular formation.
Xu W, et al. Am J Physiol Lung Cell Mol Physiol 305, L953-63 (2013).
ADAM17, shedding, TACE as therapeutic targets.
Rose-John S. Pharmacol Res 71, 19-22 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
Pep_M12B_propep (pfam01562)
  Reprolysin family propeptide.
ZnMc (cl00064)
  Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
Disintegrin (cl10507)
  Disintegrin.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Adam17 includes H.sapiens ADAM17 and R.norvegicus Adam17.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 8 species)
Mammalia - mammals (13 transcripts, 13 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (9 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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