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HomoloGene:6910. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DIS3,  H.sapiens
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
    NP_055768.3
958 aa
   DIS3,  P.troglodytes
DIS3 mitotic control homolog (S. cerevisiae)
    XP_509678.2
958 aa
   DIS3,  M.mulatta
DIS3 mitotic control homolog (S. cerevisiae)
    XP_001083933.1
948 aa
   DIS3,  C.lupus
DIS3 mitotic control homolog (S. cerevisiae)
    XP_542610.3
958 aa
   DIS3,  B.taurus
DIS3 mitotic control homolog (S. cerevisiae)
    XP_002691932.2
909 aa
   Dis3,  M.musculus
DIS3 mitotic control homolog (S. cerevisiae)
    NP_082591.2
958 aa
   Dis3,  R.norvegicus
DIS3 mitotic control homolog (S. cerevisiae)
    NP_001120955.1
957 aa
   DIS3,  G.gallus
DIS3 mitotic control homolog (S. cerevisiae)
    XP_417016.3
997 aa
   dis3,  X.tropicalis
DIS3 mitotic control homolog
    NP_001120564.1
951 aa
   dis3,  D.rerio
DIS3 mitotic control homolog (S. cerevisiae)
    XP_001336850.2
950 aa
   Dis3,  D.melanogaster
Dis3
    NP_001262910.1
982 aa
   AgaP_AGAP005191,  A.gambiae
AgaP_AGAP005191
    XP_314089.3
967 aa
   dis-3,  C.elegans
dis-3
    NP_501835.2
961 aa
   DIS3,  S.cerevisiae
DIS3
    NP_014621.1
1001 aa
   KLLA0A10835g,  K.lactis
KLLA0A10835g
    XP_451472.1
1008 aa
   AGOS_AEL031C,  E.gossypii
AGOS_AEL031C
    NP_984830.1
997 aa
   dis3,  S.pombe
dis3
    NP_596653.1
970 aa
   MGG_00193,  M.oryzae
MGG_00193
    XP_003718924.1
990 aa
   NCU03065,  N.crassa
NCU03065
    XP_963787.1
1013 aa
   EMB2763,  A.thaliana
EMB2763
    NP_001189541.1
1012 aa
   Os03g0129200,  O.sativa
Os03g0129200
    NP_001048846.1
896 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Endonucleolytic RNA cleavage by a eukaryotic exosome.
Lebreton A, et al. Nature 456, 993-6 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
RNB (pfam00773)
  RNB domain.
S1_like (cl09927)
  S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
S1_like (cl09927)
  S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
PIN_SF (cl14812)
  PIN (PilT N terminus) domain: Superfamily.
RNB (cl19762)
  This domain is the catalytic domain of ribonuclease II.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dis3 includes H.sapiens DIS3 and R.norvegicus Dis3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (12 transcripts, 8 species)
Mammalia - mammals (11 transcripts, 9 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (39 transcripts, 24 species)
Liliopsida - monocots (8 transcripts, 8 species)
Coniferopsida - conifers (2 transcripts, 2 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

Ciliophora
Oligohymenophorea - ciliates (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

 

 

 

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