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HomoloGene:30958. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FBN1,  H.sapiens
fibrillin 1
    NP_000129.3
2871 aa
   FBN1,  P.troglodytes
fibrillin 1
    XP_001149266.3
3021 aa
   FBN1,  M.mulatta
fibrillin 1
    XP_001113107.2
3021 aa
   FBN1,  C.lupus
fibrillin-1
    XP_861706.2
2871 aa
   FBN1,  B.taurus
fibrillin 1
    NP_776478.1
2871 aa
   Fbn1,  M.musculus
fibrillin 1
    NP_032019.2
2873 aa
   Fbn1,  R.norvegicus
fibrillin 1
    NP_114013.1
2872 aa
   FBN1,  G.gallus
fibrillin 1
    XP_413815.4
2768 aa
   fbn1,  X.tropicalis
fibrillin 1
    XP_002936615.2
2866 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ectopia lentis, familial.
Aortic aneurysm, ascending, and dissection.
Marfan syndrome.
Shprintzen-Goldberg syndrome.
MASS syndrome.
Weill-Marchesani syndrome, dominant.



Publications
Articles associated with genes and sequences of this homology group.




Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TB (pfam00683)
  TB domain.
EGF_CA (pfam07645)
  Calcium-binding EGF domain.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
TB (pfam00683)
  TB domain.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fbn1 includes H.sapiens FBN1 and R.norvegicus Fbn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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