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HomoloGene:55580. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   ERN1,  H.sapiens
endoplasmic reticulum to nucleus signaling 1
    NP_001424.3
977 aa
   ERN1,  P.troglodytes
endoplasmic reticulum to nucleus signaling 1
    XP_511585.3
977 aa
   ERN1,  M.mulatta
endoplasmic reticulum to nucleus signaling 1
    XP_001109583.2
978 aa
   ERN1,  C.lupus
endoplasmic reticulum to nucleus signaling 1
    XP_853409.3
975 aa
   ERN1,  B.taurus
endoplasmic reticulum to nucleus signaling 1
    XP_002696144.1
985 aa
   Ern1,  M.musculus
endoplasmic reticulum (ER) to nucleus signalling 1
    NP_076402.1
977 aa
   Ern1,  R.norvegicus
endoplasmic reticulum to nucleus signaling 1
    NP_001178855.1
965 aa
   LOC417414,  G.gallus
serine/threonine-protein kinase/endoribonuclease IRE1
    XP_004946240.1
968 aa
   ern2,  X.tropicalis
endoplasmic reticulum to nucleus signaling 2
    NP_001072279.1
957 aa
   ern2,  D.rerio
endoplasmic reticulum to nucleus signaling 2
    XP_001919350.3
930 aa
   Ire1,  D.melanogaster
Inositol-requiring enzyme-1
    NP_001097839.1
1074 aa
   AgaP_AGAP004176,  A.gambiae
AgaP_AGAP004176
    XP_562694.4
1169 aa
   ire-1,  C.elegans
ire-1
    NP_001254135.1
967 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Establishment of a new detection system for the dimerization of IRE1α by BiFC assay.
Shinjo S, et al. Biosci Biotechnol Biochem 77, 1333-6 (2013).
Oligomerization of the transmembrane domain of IRE1α in SDS micelles.
Cho H, et al. Biochem Biophys Res Commun 427, 764-7 (2012).
Modulating stress responses by the UPRosome: a matter of life and death.
Woehlbier U & Hetz C. Trends Biochem Sci 36, 329-37 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Luminal_IRE1_like (cl14874)
  The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
Pkinase (pfam00069)
  Protein kinase domain.
RNase_Ire1_like (cl15368)
  RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ern1 includes H.sapiens ERN1 and R.norvegicus Ern1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (11 transcripts, 6 species)
Mammalia - mammals (7 transcripts, 7 species)
Aves - birds (3 transcripts, 1 species)
Amphibia - amphibians (3 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 1 species)

Arthropoda
Insecta - insects (5 transcripts, 5 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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