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HomoloGene:183. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   KCNA1,  H.sapiens
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    NP_000208.2
495 aa
   KCNA1,  P.troglodytes
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_003313484.1
495 aa
   KCNA1,  M.mulatta
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_001102027.2
1127 aa
   KCNA1,  C.lupus
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_005637320.1
495 aa
   KCNA1,  B.taurus
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_005207261.1
495 aa
   Kcna1,  M.musculus
potassium voltage-gated channel, shaker-related subfamily, member 1
    NP_034725.3
495 aa
   Kcna1,  R.norvegicus
potassium voltage-gated channel, shaker-related subfamily, member 1
    NP_775118.1
495 aa
   KCNA1,  G.gallus
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
    XP_004938130.1
575 aa
   LOC100492822,  X.tropicalis
potassium voltage-gated channel subfamily A member 1-like
    XP_004912859.1
489 aa
   LOC795942,  D.rerio
potassium voltage-gated channel subfamily A member 1-like
    XP_005163101.1
492 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Episodic ataxia/myokymia syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Clinical, genetic, neurophysiological and functional study of new mutations in episodic ataxia type 1.
Tomlinson SE, et al. J Neurol Neurosurg Psychiatry 84, 1107-12 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
K_tetra (pfam02214)
  K+ channel tetramerisation domain.
Ion_trans (pfam00520)
  Ion transport protein.
BTB (cl02518)
  BTB/POZ domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kcna1 includes H.sapiens KCNA1 and R.norvegicus Kcna1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (13 transcripts, 8 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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