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HomoloGene:428. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   FGA,  H.sapiens
fibrinogen alpha chain
    NP_000499.1
866 aa
   FGA,  P.troglodytes
fibrinogen alpha chain
    XP_001136067.1
866 aa
   FGA,  M.mulatta
fibrinogen alpha chain
    XP_001088855.2
889 aa
   FGA,  C.lupus
fibrinogen alpha chain
    XP_532697.2
892 aa
   Fga,  M.musculus
fibrinogen alpha chain
    NP_001104518.1
789 aa
   Fga,  R.norvegicus
fibrinogen alpha chain
    NP_001008724.1
782 aa
   FGA,  G.gallus
fibrinogen alpha chain
    NP_001258840.1
741 aa
   fga,  X.tropicalis
fibrinogen alpha chain
    XP_002933535.2
759 aa
   fga,  D.rerio
fibrinogen alpha chain
    NP_001181918.1
684 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Amyloidosis, hereditary renal.
Dysfibrinogenemia, alpha type, causing bleeding diathesis.
Dysfibrinogenemia, alpha type, causing recurrent thrombosis.
Afibrinogenemia, congenital.



Publications
Articles associated with genes and sequences of this homology group.

Role of fibrinogen in acute ischemic kidney injury.
Sörensen-Zender I, et al. Am J Physiol Renal Physiol 305, F777-85 (2013).
Proteomic profiling of serum from stage I lung squamous cell carcinoma patients.
Li XJ, et al. Asian Pac J Cancer Prev 14, 2273-6 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fib_alpha (pfam08702)
  Fibrinogen alpha/beta chain family.
CTD (smart01104)
  Spt5 C-terminal nonapeptide repeat binding Spt4.
Fibrinogen_aC (pfam12160)
  Fibrinogen alpha C domain.
Fibrinogen_aC (pfam12160)
  Fibrinogen alpha C domain.
FReD (cl00085)
  Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fga includes H.sapiens FGA and R.norvegicus Fga.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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