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HomoloGene:308. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   THBD,  H.sapiens
thrombomodulin
    NP_000352.1
575 aa
   THBD,  P.troglodytes
thrombomodulin
    XP_525283.2
575 aa
   THBD,  M.mulatta
thrombomodulin
    XP_001095416.1
570 aa
   THBD,  C.lupus
thrombomodulin
    NP_001006954.1
578 aa
   THBD,  B.taurus
thrombomodulin
    NP_001159994.1
578 aa
   Thbd,  M.musculus
thrombomodulin
    NP_033404.1
577 aa
   Thbd,  R.norvegicus
thrombomodulin
    NP_113959.1
577 aa
   THBD,  G.gallus
thrombomodulin
    XP_004940194.1
549 aa
   thbd,  X.tropicalis
thrombomodulin
    XP_002936969.1
542 aa
   LOC100497748,  X.tropicalis
thrombomodulin-like
    XP_002936963.1
519 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Myocardial infarction, susceptibility to.
Thrombophilia due to thrombomodulin defect.



Publications
Articles associated with genes and sequences of this homology group.

Thrombomodulin regulates keratinocyte differentiation and promotes wound healing.
Cheng TL, et al. J Invest Dermatol 133, 1638-45 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tme5_EGF_like (pfam09064)
  Thrombomodulin like fifth domain, EGF-like.
EGF_CA (pfam07645)
  Calcium-binding EGF domain.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Arena_RNA_pol (pfam06317)
  Arenavirus RNA polymerase.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
vWFA (cl00057)
  Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
CLECT (cl02432)
  C-type lectin (CTL)/C-type lectin-like (CTLD) domain.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Thbd includes H.sapiens THBD and R.norvegicus Thbd.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)

 

 

 

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