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HomoloGene:52414. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   DOCK8,  H.sapiens
dedicator of cytokinesis 8
    NP_982272.2
2099 aa
   DOCK8,  P.troglodytes
dedicator of cytokinesis 8
    XP_003312029.1
2031 aa
   LOC698081,  M.mulatta
dedicator of cytokinesis protein 8-like
    XP_002808151.1
1998 aa
   DOCK8,  C.lupus
dedicator of cytokinesis 8
    XP_005615946.1
2033 aa
   DOCK8,  B.taurus
dedicator of cytokinesis 8
    NP_001178461.1
2098 aa
   Dock8,  M.musculus
dedicator of cytokinesis 8
    NP_083061.2
2100 aa
   Dock8,  R.norvegicus
dedicator of cytokinesis 8
    NP_001032882.2
2099 aa
   DOCK8,  G.gallus
dedicator of cytokinesis 8
    XP_424926.4
2104 aa
   dock8,  X.tropicalis
dedicator of cytokinesis 8
    XP_002935647.2
2089 aa
   dock8,  D.rerio
dedicator of cytokinesis 8
    XP_001920107.4
2090 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mental retardation, autosomal dominant 2.



Publications
Articles associated with genes and sequences of this homology group.

Cutaneous manifestations of DOCK8 deficiency syndrome.
Chu EY, et al. Arch Dermatol 148, 79-84 (2012).
The essential role of DOCK8 in humoral immunity.
Randall KL, et al. Dis Markers 29, 141-50 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3398 (pfam11878)
  Domain of unknown function (DUF3398).
DHR2_DOCK (cl06123)
  Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins.
DUF3398 (pfam11878)
  Domain of unknown function (DUF3398).
DHR2_DOCK (cl06123)
  Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins.
C2 (cl14603)
  C2 domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dock8 includes H.sapiens DOCK8 and R.norvegicus Dock8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 13 species)
Actinopterygii - bony fishes (15 transcripts, 7 species)
Aves - birds (4 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

 

 

 

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