Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:1551. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   GATA4,  H.sapiens
GATA binding protein 4
    NP_002043.2
442 aa
   GATA4,  P.troglodytes
GATA binding protein 4
    XP_528070.3
408 aa
   GATA4,  M.mulatta
GATA binding protein 4
    XP_001087008.2
443 aa
   GATA4,  C.lupus
GATA binding protein 4
    NP_001041577.1
442 aa
   GATA4,  B.taurus
GATA binding protein 4
    NP_001179806.1
442 aa
   Gata4,  M.musculus
GATA binding protein 4
    NP_032118.2
441 aa
   Gata4,  R.norvegicus
GATA binding protein 4
    NP_653331.1
440 aa
   GATA4,  G.gallus
GATA binding protein 4
    XP_420041.1
410 aa
   gata4,  X.tropicalis
GATA binding protein 4
    NP_001016949.1
394 aa
   gata4,  D.rerio
GATA-binding protein 4
    XP_005160990.1
352 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Atrial septal defect-2.



Publications
Articles associated with genes and sequences of this homology group.

Decreased expression of GATA4 in the diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Dingemann J, et al. Birth Defects Res B Dev Reprod Toxicol 98, 139-43 (2013).
Dissociation of cardiogenic and postnatal myocardial activities of GATA4.
Gallagher JM, et al. Mol Cell Biol 32, 2214-23 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
GATA-N (pfam05349)
  GATA-type transcription activator, N-terminal.
GATA-N (pfam05349)
  GATA-type transcription activator, N-terminal.
ZnF_GATA (cl00158)
  Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Gata4 includes H.sapiens GATA4 and R.norvegicus Gata4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

 

 

 

Write to the Help Desk