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HomoloGene:21428. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   STAT1,  H.sapiens
signal transducer and activator of transcription 1, 91kDa
    NP_009330.1
750 aa
   STAT1,  P.troglodytes
signal transducer and activator of transcription 1, 91kDa
    XP_003309418.1
714 aa
   STAT1,  M.mulatta
signal transducer and activator of transcription 1, 91kDa
    XP_002799062.1
750 aa
   LOC488449,  C.lupus
signal transducer and activator of transcription 1-like
    XP_848353.1
750 aa
   STAT1,  B.taurus
signal transducer and activator of transcription 1, 91kDa
    NP_001071368.1
712 aa
   Stat1,  M.musculus
signal transducer and activator of transcription 1
    NP_001192242.1
755 aa
   Stat1,  R.norvegicus
signal transducer and activator of transcription 1
    NP_116001.2
749 aa
   STAT1,  G.gallus
signal transducer and activator of transcription 1, 91kDa
    NP_001012932.1
755 aa
   stat1,  X.tropicalis
signal transducer and activator of transcription 1, 91kDa
    NP_001072935.1
648 aa
   stat1a,  D.rerio
signal transduction and activation of transcription 1a
    NP_571555.1
749 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Mycobacterial infection, atypical, familial disseminated.
STAT1 deficiency, complete.



Publications
Articles associated with genes and sequences of this homology group.

Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response.
Hannesdóttir L, et al. Eur J Immunol 43, 2718-29 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
STAT_bind (pfam02864)
  STAT protein, DNA binding domain.
STAT1_TAZ2bind (pfam12162)
  STAT1 TAZ2 binding domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
STAT_alpha (pfam01017)
  STAT protein, all-alpha domain.
STAT_int (cl03749)
  STAT protein, protein interaction domain.
SH2 (cl15255)
  Src homology 2 (SH2) domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stat1 includes H.sapiens STAT1 and R.norvegicus Stat1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 17 species)
Actinopterygii - bony fishes (16 transcripts, 11 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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