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HomoloGene:3023. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   EMX2,  H.sapiens
empty spiracles homeobox 2
    NP_004089.1
252 aa
   EMX2,  P.troglodytes
empty spiracles homeobox 2
    XP_001152098.1
252 aa
   EMX2,  M.mulatta
empty spiracles homeobox 2
    XP_001095904.1
252 aa
   EMX2,  C.lupus
empty spiracles homeobox 2
    XP_853333.1
253 aa
   EMX2,  B.taurus
empty spiracles homeobox 2
    NP_001069313.1
253 aa
   Emx2,  M.musculus
empty spiracles homeobox 2
    NP_034262.2
253 aa
   Emx2,  R.norvegicus
empty spiracles homeobox 2
    NP_001102639.1
253 aa
   EMX2,  G.gallus
empty spiracles homeobox 2
    XP_421783.2
247 aa
   emx2,  X.tropicalis
empty spiracles homeobox 2
    NP_001128284.1
247 aa
   emx2,  D.rerio
empty spiracles homeobox 2
    NP_571355.2
247 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Schizencephaly.



Publications
Articles associated with genes and sequences of this homology group.

No major role for the EMX2 gene in schizencephaly.
Merello E, et al. Am J Med Genet A 146A, 1142-50 (2008).
Comprehensive EMX2 genotyping of a large schizencephaly case series.
Tietjen I, et al. Am J Med Genet A 143A, 1313-6 (2007).
Microarray analysis of the fetal hippocampus in the Emx2 mutant.
Skutella T, et al. Dev Neurosci 29, 28-47 (2007).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Emx2 includes H.sapiens EMX2 and R.norvegicus Emx2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 5 species)
Aves - birds (4 transcripts, 2 species)
Cephalochordata - lancelets (3 transcripts, 1 species)
Hyperoartia - vertebrates (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

 

 

 

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