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HomoloGene:2744. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   TNFSF11,  H.sapiens
tumor necrosis factor (ligand) superfamily, member 11
    NP_003692.1
317 aa
   TNFSF11,  P.troglodytes
tumor necrosis factor (ligand) superfamily, member 11
    XP_522750.3
317 aa
   TNFSF11,  M.mulatta
tumor necrosis factor (ligand) superfamily, member 11
    XP_001092669.1
317 aa
   TNFSF11,  C.lupus
tumor necrosis factor (ligand) superfamily, member 11
    XP_851765.1
315 aa
   TNFSF11,  B.taurus
tumor necrosis factor (ligand) superfamily, member 11
    NP_001192699.1
316 aa
   Tnfsf11,  M.musculus
tumor necrosis factor (ligand) superfamily, member 11
    NP_035743.2
316 aa
   Tnfsf11,  R.norvegicus
tumor necrosis factor (ligand) superfamily, member 11
    XP_006252436.1
318 aa
   TNFSF11,  G.gallus
tumor necrosis factor (ligand) superfamily, member 11
    NP_001076830.1
400 aa
   tnfsf11,  X.tropicalis
tumor necrosis factor (ligand) superfamily, member 11
    XP_002938089.1
290 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Osteopetrosis, autosomal recessive 2.



Publications
Articles associated with genes and sequences of this homology group.

RANK expression on breast cancer cells promotes skeletal metastasis.
Blake ML, et al. Clin Exp Metastasis 31, 233-45 (2014).
RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease.
Lo Iacono N, et al. Clin Dev Immunol 2013, 412768 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TNF (cl00147)
  Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tnfsf11 includes H.sapiens TNFSF11 and R.norvegicus Tnfsf11.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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