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HomoloGene:488. Gene conserved in Boreoeutheria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IL2,  H.sapiens
interleukin 2
    NP_000577.2
153 aa
   IL2,  P.troglodytes
interleukin 2
    XP_517425.1
153 aa
   IL2,  M.mulatta
interleukin 2
    NP_001040595.1
154 aa
   IL2,  C.lupus
interleukin 2
    NP_001003305.1
155 aa
   Il2,  M.musculus
interleukin 2
    NP_032392.1
169 aa
   Il2,  R.norvegicus
interleukin 2
    NP_446288.1
155 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Severe combined immunodeficiency due to IL2 deficiency.



Publications
Articles associated with genes and sequences of this homology group.

IL-2 coordinates IL-2-producing and regulatory T cell interplay.
Amado IF, et al. J Exp Med 210, 2707-20 (2013).
Modeling interleukin-2-based immunotherapy in AIDS pathogenesis.
Joly M & Odloak D. J Theor Biol 335, 57-78 (2013).
Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.
Carmenate T, et al. J Immunol 190, 6230-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IL2 (cl11593)
  Interleukin-2 is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. This protein is required for T-cell proliferation and other activities crucial to the regulation of the immune response.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il2 includes H.sapiens IL2 and R.norvegicus Il2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)

 

 

 

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