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HomoloGene:4454. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PRMT5,  H.sapiens
protein arginine methyltransferase 5
    NP_006100.2
637 aa
   PRMT5,  P.troglodytes
protein arginine methyltransferase 5
    XP_509844.3
637 aa
   PRMT5,  M.mulatta
protein arginine methyltransferase 5
    XP_001103964.1
644 aa
   PRMT5,  C.lupus
protein arginine methyltransferase 5
    XP_537366.2
637 aa
   PRMT5,  B.taurus
protein arginine methyltransferase 5
    NP_001098844.1
637 aa
   Prmt5,  M.musculus
protein arginine N-methyltransferase 5
    NP_038796.2
637 aa
   Prmt5,  R.norvegicus
protein arginine methyltransferase 5
    NP_001102337.2
637 aa
   prmt5,  X.tropicalis
protein arginine methyltransferase 5
    XP_002941557.1
633 aa
   prmt5,  D.rerio
protein arginine methyltransferase 5
    NP_001007184.2
631 aa
   csul,  D.melanogaster
capsuleen
    NP_725552.1
605 aa
   AgaP_AGAP009048,  A.gambiae
AgaP_AGAP009048
    XP_319800.4
629 aa
   SKB1,  A.thaliana
SKB1
    NP_194841.2
642 aa
   Os02g0139200,  O.sativa
Os02g0139200
    NP_001045843.1
649 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Versatility of PRMT5-induced methylation in growth control and development.
Karkhanis V, et al. Trends Biochem Sci 36, 633-41 (2011).
A germ cell-specific gene, Prmt5, works in somatic cell reprogramming.
Nagamatsu G, et al. J Biol Chem 286, 10641-8 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PRMT5 (pfam05185)
  PRMT5 arginine-N-methyltransferase.
AdoMet_MTases (cl17173)
  S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
PRMT5 (cl17640)
  PRMT5 arginine-N-methyltransferase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prmt5 includes H.sapiens PRMT5 and R.norvegicus Prmt5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 14 species)
Actinopterygii - bony fishes (16 transcripts, 10 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (3 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (33 transcripts, 26 species)
Liliopsida - monocots (8 transcripts, 7 species)
Bryopsida - mosses (2 transcripts, 1 species)
Coniferopsida - conifers (2 transcripts, 2 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 2 species)
Eurotiomycetes - ascomycetes (2 transcripts, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Oomycetes
Pythiales - oomycetes (1 transcript, 1 species)

 

 

 

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