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HomoloGene:292. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   SMN1,  H.sapiens
survival of motor neuron 1, telomeric
    NP_075012.1
262 aa
   SMN2,  H.sapiens
survival of motor neuron 2, centromeric
    NP_075014.1
262 aa
   SMN1,  P.troglodytes
survival of motor neuron 1, telomeric
    XP_001156259.1
262 aa
   SMN1,  M.mulatta
survival of motor neuron 1, telomeric
    XP_001096348.2
294 aa
   SMN,  C.lupus
survival motor neuron
    NP_001003226.1
287 aa
   SMN1,  B.taurus
survival of motor neuron 1, telomeric
    NP_783632.1
287 aa
   Smn1,  M.musculus
survival motor neuron 1
    NP_035550.1
288 aa
   Smn1,  R.norvegicus
survival of motor neuron 1, telomeric
    NP_071954.1
289 aa
   SMN,  G.gallus
survival of motor neuron
    NP_989530.1
264 aa
   smn2,  X.tropicalis
survival of motor neuron 2, centromeric
    NP_001093710.1
282 aa
   smn1,  D.rerio
survival motor neuron 1
    NP_571266.1
281 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Spinal muscular atrophy-1.
Spinal muscular atrophy-3.
Spinal muscular atrophy-2.
Spinal muscular atrophy-4.
Spinal muscular atrophy, type III, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

Temporal requirement for SMN in motoneuron development.
Hao le T, et al. Hum Mol Genet 22, 2612-25 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TUDOR (cl02573)
  Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smn1 includes H.sapiens SMN1 and R.norvegicus Smn1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 12 species)
Actinopterygii - bony fishes (9 transcripts, 9 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

 

 

 

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