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HomoloGene:206. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   MET,  H.sapiens
met proto-oncogene
    NP_001120972.1
1408 aa
   MET,  P.troglodytes
met proto-oncogene (hepatocyte growth factor receptor)
    NP_001129302.1
1390 aa
   MET,  M.mulatta
met proto-oncogene (hepatocyte growth factor receptor)
    NP_001162100.1
1381 aa
   MET,  C.lupus
met proto-oncogene (hepatocyte growth factor receptor)
    NP_001002963.1
1382 aa
   MET,  B.taurus
met proto-oncogene (hepatocyte growth factor receptor)
    NP_001013017.2
1384 aa
   Met,  M.musculus
met proto-oncogene
    NP_032617.2
1379 aa
   Met,  R.norvegicus
met proto-oncogene
    NP_113705.1
1382 aa
   MET,  G.gallus
met proto-oncogene (hepatocyte growth factor receptor)
    NP_990543.1
1382 aa
   met,  X.tropicalis
met proto-oncogene (hepatocyte growth factor receptor)
    XP_002935001.1
1375 aa
   met,  D.rerio
met proto-oncogene (hepatocyte growth factor receptor)
    NP_001007125.1
1382 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hepatocellular carcinoma, childhood type.
Renal cell carcinoma, papillary, familial and sporadic.
Autism, suseptibility to, 9.



Publications
Articles associated with genes and sequences of this homology group.

[Increased expression of the c-Met receptor mRNA in gastric cancer].
Amemiya H, et al. Invest Clin 54, 284-98 (2013).
Met signaling in cardiomyocytes is required for normal cardiac function in adult mice.
Arechederra M, et al. Biochim Biophys Acta 1832, 2204-15 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PSI (pfam01437)
  Plexin repeat.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.
PSI (cl02601)
  A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Sema (cl15693)
  The Sema domain, a protein interacting module, of semaphorins and plexins.
IPT (cl15674)
  Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Met includes H.sapiens MET and R.norvegicus Met.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

 

 

 

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