Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
HomoloGene:7782. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   IKBKB,  H.sapiens
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_001547.1
756 aa
   IKBKB,  P.troglodytes
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    XP_001142461.2
747 aa
   IKBKB,  M.mulatta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    XP_001096913.1
756 aa
   IKBKB,  C.lupus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    XP_005629860.1
759 aa
   IKBKB,  B.taurus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_776778.1
756 aa
   Ikbkb,  M.musculus
inhibitor of kappaB kinase beta
    NP_001153246.1
757 aa
   Ikbkb,  R.norvegicus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_445807.2
757 aa
   IKBKB,  G.gallus
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_001026568.1
739 aa
   ikbkb,  X.tropicalis
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_001005651.1
742 aa
   ikbkb,  D.rerio
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    NP_001116737.1
779 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al. N Engl J Med 369, 2504-14 (2013).
Role of IκB kinase-β in the growth-promoting effects of angiotensin II in vitro and in vivo.
Doyon P, et al. Arterioscler Thromb Vasc Biol 33, 2850-7 (2013).
Crystal structure of a human IκB kinase β asymmetric dimer.
Liu S, et al. J Biol Chem 288, 22758-67 (2013).
Ubiquitin-like domain of IKKβ regulates osteoclastogenesis and osteolysis.
Zhang Y, et al. Calcif Tissue Int 93, 78-85 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IKKbetaNEMObind (pfam12179)
  I-kappa-kinase-beta NEMO binding domain.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
UBL_TBK1_like (cd12219)
  Ubiquitin-Like Domain Of Human Tbk1 and similar proteins.
UBQ (cl00155)
  Ubiquitin-like proteins.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ikbkb includes H.sapiens IKBKB and R.norvegicus Ikbkb.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 10 species)
Actinopterygii - bony fishes (9 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

Write to the Help Desk