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HomoloGene:4118. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SOX3,  H.sapiens
SRY (sex determining region Y)-box 3
446 aa
   SOX3,  M.mulatta
SRY (sex determining region Y)-box 3
446 aa
   SOX3,  C.lupus
SRY (sex determining region Y)-box 3
444 aa
   Sox3,  M.musculus
SRY (sex determining region Y)-box 3
450 aa
   SOX3,  G.gallus
SRY (sex determining region Y)-box 3
316 aa
   sox3,  X.tropicalis
SRY (sex determining region Y)-box 3
307 aa
   sox3,  D.rerio
SRY-box containing gene 3
300 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Mental retardation, X-linked, with isolated growth hormone deficiency.
Infundibular hypoplasia and hypopituitarism.

Articles associated with genes and sequences of this homology group.

X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26.
Lagerström-Fermér M, et al. Am J Hum Genet 60, 910-6 (1997).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SOXp (pfam12336)
  SOX transcription factor.
HMG-box (cl00082)
  High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sox3 includes H.sapiens SOX3 and R.norvegicus Sox3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Actinopterygii - bony fishes (8 transcripts, 8 species)
Mammalia - mammals (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Hirudinida - segmented worms (1 transcript, 1 species)




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