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HomoloGene:5182. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TFEB,  H.sapiens
transcription factor EB
490 aa
   TFEB,  P.troglodytes
transcription factor EB
490 aa
   TFEB,  M.mulatta
transcription factor EB
490 aa
   TFEB,  C.lupus
transcription factor EB
475 aa
   TFEB,  B.taurus
transcription factor EB
478 aa
   Tfeb,  M.musculus
transcription factor EB
534 aa
   Tfeb,  R.norvegicus
transcription factor EB
535 aa
   TFEB,  G.gallus
transcription factor EB
455 aa
   tfeb,  X.tropicalis
transcription factor EB
433 aa
   tfeb,  D.rerio
transcription factor EB
493 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease.
Spampanato C, et al. EMBO Mol Med 5, 691-706 (2013).
TFEB regulates lysosomal proteostasis.
Song W, et al. Hum Mol Genet 22, 1994-2009 (2013).
Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient.
Pecciarini L, et al. Genes Chromosomes Cancer 46, 419-26 (2007).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF3371 (pfam11851)
  Domain of unknown function (DUF3371).
DUF3371 (pfam11851)
  Domain of unknown function (DUF3371).
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tfeb includes H.sapiens TFEB.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)




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