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HomoloGene:11085. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   OPTN,  H.sapiens
optineurin
    NP_068815.2
577 aa
   OPTN,  P.troglodytes
optineurin
    XP_001139979.1
577 aa
   OPTN,  M.mulatta
optineurin
    NP_001028069.1
571 aa
   OPTN,  C.lupus
optineurin
    XP_535187.4
573 aa
   OPTN,  B.taurus
optineurin
    NP_001029774.1
573 aa
   Optn,  M.musculus
optineurin
    NP_862896.1
584 aa
   Optn,  R.norvegicus
optineurin
    NP_659549.2
586 aa
   OPTN,  G.gallus
optineurin
    NP_989567.1
556 aa
   optn,  X.tropicalis
optineurin
    XP_004913094.1
538 aa
   optn,  D.rerio
optineurin
    NP_001093536.2
524 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Glaucoma 1, open angle, E.
Glaucoma, normal tension, susceptibility to.



Publications
Articles associated with genes and sequences of this homology group.

Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese.
Iida A, et al. Neurobiol Aging 33, 1843.e19-24 (2012).
Cellular and molecular biology of optineurin.
Ying H & Yue BY. Int Rev Cell Mol Biol 294, 223-58 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NEMO (pfam11577)
  NF-kappa-B essential modulator NEMO.
UBAN (cd09803)
  polyubiquitin binding domain of NEMO and related proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Optn includes H.sapiens OPTN and R.norvegicus Optn.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 15 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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