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HomoloGene:74. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   COMP,  H.sapiens
cartilage oligomeric matrix protein
    NP_000086.2
757 aa
   COMP,  P.troglodytes
cartilage oligomeric matrix protein
    NP_001092035.1
757 aa
   COMP,  M.mulatta
cartilage oligomeric matrix protein
    XP_001115565.1
757 aa
   COMP,  C.lupus
cartilage oligomeric matrix protein
    XP_533869.2
756 aa
   COMP,  B.taurus
cartilage oligomeric matrix protein
    NP_001159989.1
756 aa
   Comp,  M.musculus
cartilage oligomeric matrix protein
    NP_057894.2
755 aa
   Comp,  R.norvegicus
cartilage oligomeric matrix protein
    NP_036966.1
755 aa
   COMP,  G.gallus
cartilage oligomeric matrix protein
    XP_418238.2
761 aa
   comp,  X.tropicalis
cartilage oligomeric matrix protein
    XP_002940251.2
752 aa
   im:7154332,  D.rerio
im:7154332
    XP_002663752.3
761 aa
   Tsp,  D.melanogaster
Thrombospondin
    NP_523495.2
1060 aa
   AgaP_AGAP002157,  A.gambiae
AgaP_AGAP002157
    XP_308033.5
1066 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Epiphyseal dysplasia, multiple 1.
Pseudoachondroplasia.



Publications
Articles associated with genes and sequences of this homology group.

[Clinical features and COMP gene mutation in a family with a pseudoachondroplasia child].
Lu CT, et al. Zhongguo Dang Dai Er Ke Za Zhi 15, 937-41 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TSP_C (pfam05735)
  Thrombospondin C-terminal region.
COMP (pfam11598)
  Cartilage oligomeric matrix protein.
TSP_3 (pfam02412)
  Thrombospondin type 3 repeat.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Comp includes H.sapiens COMP and R.norvegicus Comp.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (29 transcripts, 10 species)
Mammalia - mammals (19 transcripts, 12 species)
Aves - birds (3 transcripts, 1 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 9 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (2 transcripts, 2 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

 

 

 

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