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HomoloGene:15442. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   SOCS4,  H.sapiens
suppressor of cytokine signaling 4
440 aa
   SOCS4,  P.troglodytes
suppressor of cytokine signaling 4
440 aa
   SOCS4,  M.mulatta
suppressor of cytokine signaling 4
440 aa
   SOCS4,  C.lupus
suppressor of cytokine signaling 6
440 aa
   SOCS4,  B.taurus
suppressor of cytokine signaling 4
440 aa
   Socs4,  M.musculus
suppressor of cytokine signaling 4
436 aa
   Socs4,  R.norvegicus
suppressor of cytokine signaling 4
436 aa
   SOCS4,  G.gallus
suppressor of cytokine signaling 4
436 aa
   socs4,  X.tropicalis
suppressor of cytokine signaling 4
436 aa
   socs9,  D.rerio
suppressor of cytokine signaling 9
497 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Negative regulation of cytokine signaling: STAT-induced STAT inhibitor.
Naka T, et al. Trends Biochem Sci 24, 394-8 (1999).
Inhibitors of cytokine signal transduction.
Wormald S & Hilton DJ. J Biol Chem 279, 821-4 (2004).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
SOCS (pfam12610)
  Suppressor of cytokine signalling.
SH2 (cl15255)
  Src homology 2 (SH2) domain.
SOCS (pfam12610)
  Suppressor of cytokine signalling.
SOCS (cl02533)
  SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
SH2 (cl15255)
  Src homology 2 (SH2) domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Socs4 includes H.sapiens SOCS4 and R.norvegicus Socs4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 9 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Aves - birds (2 transcripts, 2 species)
Hyperoartia - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Chromadorea - nematodes (2 transcripts, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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