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HomoloGene:11171. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PI4KA,  H.sapiens
phosphatidylinositol 4-kinase, catalytic, alpha
    NP_477352.3
2102 aa
   PI4KA,  P.troglodytes
phosphatidylinositol 4-kinase, catalytic, alpha
    XP_525639.3
2098 aa
   PI4KA,  M.mulatta
phosphatidylinositol 4-kinase, catalytic, alpha
    XP_001086542.2
2086 aa
   PI4KA,  C.lupus
phosphatidylinositol 4-kinase, catalytic, alpha
    XP_543569.5
2130 aa
   PI4KA,  B.taurus
phosphatidylinositol 4-kinase, catalytic, alpha
    NP_777002.1
2043 aa
   Pi4ka,  M.musculus
phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
    NP_001001983.2
2044 aa
   Pi4ka,  R.norvegicus
phosphatidylinositol 4-kinase, catalytic, alpha
    NP_071637.1
2041 aa
   PI4KA,  G.gallus
phosphatidylinositol 4-kinase, catalytic, alpha
    XP_004945537.1
2123 aa
   pi4ka,  X.tropicalis
phosphatidylinositol 4-kinase, catalytic, alpha
    NP_001238804.1
2061 aa
   pi4kaa,  D.rerio
phosphatidylinositol 4-kinase, catalytic, alpha a
    NP_001030144.1
2059 aa
   PI4KIIIalpha,  D.melanogaster
Phosphatidylinositol 4-kinase III alpha
    NP_570014.3
2134 aa
   AgaP_AGAP010801,  A.gambiae
AgaP_AGAP010801
    XP_318507.4
2067 aa
   CELE_Y75B8A.24,  C.elegans
CELE_Y75B8A.24
    NP_499596.2
2106 aa
   ATPI4K ALPHA,  A.thaliana
ATPI4K ALPHA
    NP_175359.2
2028 aa
   Os03g0711200,  O.sativa
Os03g0711200
    NP_001051054.1
608 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Genetic and functional studies of phosphatidyl-inositol 4-kinase type IIIα.
Szentpetery Z, et al. Biochim Biophys Acta 1811, 476-83 (2011).
Failure to confirm association between PIK4CA and psychosis in 22q11.2 deletion syndrome.
Ikeda M, et al. Am J Med Genet B Neuropsychiatr Genet 153B, 980-2 (2010).
Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome.
Vorstman JA, et al. Am J Med Genet B Neuropsychiatr Genet 150B, 430-3 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PI3Ka (cl00271)
  Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
PI3Kc_like (cl00119)
  Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pi4ka includes H.sapiens PI4KA and R.norvegicus Pi4ka.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (28 transcripts, 8 species)
Mammalia - mammals (19 transcripts, 9 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (31 transcripts, 24 species)
Liliopsida - monocots (14 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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