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HomoloGene:324. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   XDH,  H.sapiens
xanthine dehydrogenase
    NP_000370.2
1333 aa
   XDH,  P.troglodytes
xanthine dehydrogenase
    XP_525729.2
1333 aa
   XDH,  M.mulatta
xanthine dehydrogenase/oxidase-like
    XP_002808080.1
1299 aa
   XDH,  C.lupus
xanthine dehydrogenase
    XP_540143.2
1333 aa
   XDH,  B.taurus
xanthine dehydrogenase
    NP_776397.1
1332 aa
   Xdh,  M.musculus
xanthine dehydrogenase
    NP_035853.2
1335 aa
   Xdh,  R.norvegicus
xanthine dehydrogenase
    NP_058850.1
1331 aa
   XDH,  G.gallus
xanthine dehydrogenase
    NP_990458.1
1358 aa
   LOC100497499,  X.tropicalis
xanthine dehydrogenase/oxidase-like
    XP_004914866.1
1210 aa
   xdh,  D.rerio
xanthine dehydrogenase
    XP_688983.3
1351 aa
   ry,  D.melanogaster
rosy
    NP_524337.1
1335 aa
   AgaP_AGAP007918,  A.gambiae
AgaP_AGAP007918
    XP_317568.3
1329 aa
   F55B11.1,  C.elegans
F55B11.1
    NP_502747.1
1358 aa
   MGG_12738,  M.oryzae
MGG_12738
    XP_003716708.1
1382 aa
   NCU03350,  N.crassa
NCU03350
    XP_956459.2
1375 aa
   XDH2,  A.thaliana
XDH2
    NP_195216.2
1353 aa
   XDH1,  A.thaliana
XDH1
    NP_195215.2
1361 aa
   Os03g0429800,  O.sativa
Os03g0429800
    NP_001050420.1
1369 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

D.melanogaster
The structural gene for xanthine dehydrogenase (XDH); it is a homodimer with subunit molecular weight estimated from its DNA sequence as 146,898 daltons (Keith, Riley, Kreitman, Lewontin, Curtis and Chambers, 1987). Enzyme level responds to dose of ry+ alleles (Grell, 1962). XDH is a molybdenum hydroxylase and requires the activity of cin+, lxd+, mal+ for normal activity, though not for normal levels of CRM (Glassman, Shinoda, Duke and Collins, 1968). CRM (cross-reacting material) contains bound molybdenum in the presence of mal; however, enzyme activity inhibited (Andres, 1976). (See FlyBase for complete description.)

H.sapiens
Xanthinuria, type I.



Publications
Articles associated with genes and sequences of this homology group.

Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.
Murakami N, et al. Arterioscler Thromb Vasc Biol 34, 44-51 (2014).
Multi-exon deletion in the XDH gene as a cause of classical xanthinuria.
Eggermann T, et al. Clin Nephrol 79, 78-80 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Fer2_2 (pfam01799)
  [2Fe-2S] binding domain.
Ald_Xan_dh_C (pfam01315)
  Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain.
Ald_Xan_dh_C2 (pfam02738)
  Molybdopterin-binding domain of aldehyde dehydrogenase.
CO_deh_flav_C (pfam03450)
  CO dehydrogenase flavoprotein C-terminal domain.
Fer2_2 (pfam01799)
  [2Fe-2S] binding domain.
Ald_Xan_dh_C2 (pfam02738)
  Molybdopterin-binding domain of aldehyde dehydrogenase.
fer2 (cl00159)
  2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
Ald_Xan_dh_C (cl03161)
  Aldehyde oxidase catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.
CO_deh_flav_C (cl08390)
  Abstract information not available
FAD_binding_4 (cl19922)
  FAD binding domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Xdh includes H.sapiens XDH and R.norvegicus Xdh.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (31 transcripts, 10 species)
Mammalia - mammals (16 transcripts, 11 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 7 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Porifera
Demospongiae - sponges (4 transcripts, 1 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)

Streptophyta
Eudicotyledons - eudicots (36 transcripts, 23 species)
Liliopsida - monocots (13 transcripts, 9 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (1 transcript, 1 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Chlorophyta
Chlorophyceae - green algae (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (5 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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