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HomoloGene:448. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   PLP1,  H.sapiens
proteolipid protein 1
    NP_000524.3
277 aa
   PLP1,  P.troglodytes
proteolipid protein 1
    XP_001141683.1
277 aa
   PLP1,  M.mulatta
proteolipid protein 1
    XP_001087984.2
277 aa
   PLP1,  C.lupus
proteolipid protein 1
    NP_001013856.1
277 aa
   PLP1,  B.taurus
proteolipid protein 1
    NP_776574.2
277 aa
   Plp1,  M.musculus
proteolipid protein (myelin) 1
    NP_035253.1
277 aa
   Plp1,  R.norvegicus
proteolipid protein 1
    NP_112252.1
277 aa
   PLP1,  G.gallus
proteolipid protein 1
    NP_990608.1
277 aa
   plp1,  X.tropicalis
proteolipid protein 1
    NP_001027507.1
280 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Pelizaeus-Merzbacher disease.
Spastic paraplegia-2.



Publications
Articles associated with genes and sequences of this homology group.

Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease.
Yu LH, et al. Mol Genet Metab 106, 108-14 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myelin_PLP (pfam01275)
  Myelin proteolipid protein (PLP or lipophilin).
Myelin_PLP (cl02417)
  Myelin proteolipid protein (PLP or lipophilin).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Plp1 includes H.sapiens PLP1 and R.norvegicus Plp1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 13 species)
Actinopterygii - bony fishes (15 transcripts, 10 species)
Aves - birds (5 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

 

 

 

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