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HomoloGene:48420. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   STK3,  H.sapiens
serine/threonine kinase 3
    NP_001243241.1
519 aa
   STK3,  P.troglodytes
serine/threonine kinase 3
    XP_003951359.1
562 aa
   STK3,  M.mulatta
serine/threonine kinase 3
    XP_001095834.2
491 aa
   STK3,  C.lupus
serine/threonine kinase 3
    XP_532280.2
491 aa
   STK3,  B.taurus
serine/threonine kinase 3
    NP_001073075.1
491 aa
   Stk3,  M.musculus
serine/threonine kinase 3
    NP_062609.2
497 aa
   Stk3,  R.norvegicus
serine/threonine kinase 3
    NP_113923.1
491 aa
   stk3,  X.tropicalis
serine/threonine kinase 3
    NP_001090665.1
493 aa
   stk3,  D.rerio
serine/threonine kinase 3 (STE20 homolog, yeast)
    NP_955966.1
492 aa
   hpo,  D.melanogaster
hippo
    NP_611427.1
669 aa
   AgaP_AGAP006044,  A.gambiae
AgaP_AGAP006044
    XP_316092.4
676 aa
   cst-1,  C.elegans
cst-1
    NP_001024575.2
497 aa
   cst-2,  C.elegans
cst-2
    NP_001041219.2
421 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

The Hippo size control pathway--ever expanding.
Lin JI, et al. Sci Signal 6, pe4 (2013).
Crystallization and preliminary X-ray crystallographic study of the human MST2 SARAH domain.
Song J, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 67, 1403-5 (2011).
The Hippo pathway and apico-basal cell polarity.
Genevet A & Tapon N. Biochem J 436, 213-24 (2011).
[Developmental control of organ growth by the Hippo pathway].
Bardet PL. Med Sci (Paris) 25, 253-7 (2009).
Hippo signaling pathway and organ size control.
Zhang L, et al. Fly (Austin) 3, 68-73 (2009).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Mst1_SARAH (pfam11629)
  C terminal SARAH domain of Mst1.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Stk3 includes H.sapiens STK3 and R.norvegicus Stk3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (17 transcripts, 14 species)
Actinopterygii - bony fishes (12 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 7 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (4 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (3 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (2 transcripts, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (2 transcripts, 2 species)
Liliopsida - monocots (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (2 transcripts, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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