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HomoloGene:2407. Gene conserved in Tetrapoda Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

   TCF4,  H.sapiens
transcription factor 4
667 aa
   TCF4,  M.mulatta
transcription factor 4
667 aa
   TCF4,  C.lupus
transcription factor 4
642 aa
   TCF4,  B.taurus
transcription factor 4
511 aa
   Tcf4,  M.musculus
transcription factor 4
670 aa
   Tcf4,  R.norvegicus
transcription factor 4
585 aa
   tcf4,  X.tropicalis
transcription factor 4
675 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Pitt-Hopkins syndrome.

Articles associated with genes and sequences of this homology group.

Mosaic 18q21.2 deletions including the TCF4 gene: a clinical report.
Rossi M, et al. Am J Med Genet A 158A, 3174-81 (2012).
TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.
Navarrete K, et al. Am J Med Genet B Neuropsychiatr Genet 162B, 1-16 (2013).
Deficits in trace fear memory in a mouse model of the schizophrenia risk gene TCF4.
Brzózka MM & Rossner MJ. Behav Brain Res 237, 348-56 (2013).
Pitt-Hopkins Syndrome
Ardinger HH, et al. (1993).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HLH (cl00081)
  Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tcf4 includes H.sapiens TCF4 and R.norvegicus Tcf4.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (15 transcripts, 13 species)
Actinopterygii - bony fishes (9 transcripts, 7 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)

Anthozoa - anthozoans (2 transcripts, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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