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HomoloGene:4504. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   NTRK2,  H.sapiens
neurotrophic tyrosine kinase, receptor, type 2
    NP_006171.2
838 aa
   NTRK2,  P.troglodytes
neurotrophic tyrosine kinase, receptor, type 2
    XP_001135326.1
838 aa
   NTRK2,  M.mulatta
neurotrophic tyrosine kinase, receptor, type 2
    XP_001107264.1
838 aa
   NTRK2,  C.lupus
neurotrophic tyrosine kinase, receptor, type 2
    XP_848589.1
838 aa
   NTRK2,  B.taurus
neurotrophic tyrosine kinase, receptor, type 2
    NP_001068693.1
476 aa
   Ntrk2,  M.musculus
neurotrophic tyrosine kinase, receptor, type 2
    NP_001269890.1
821 aa
   Ntrk2,  R.norvegicus
neurotrophic tyrosine kinase, receptor, type 2
    NP_036863.1
821 aa
   NTRK2,  G.gallus
neurotrophic tyrosine kinase, receptor, type 2
    NP_990562.1
818 aa
   ntrk2,  X.tropicalis
neurotrophic tyrosine kinase, receptor, type 2
    NP_001072653.1
821 aa
   ntrk2a,  D.rerio
neurotrophic tyrosine kinase, receptor, type 2a
    XP_003199193.2
826 aa
   ntrk2b,  D.rerio
neurotrophic tyrosine kinase, receptor, type 2b
    NP_001184090.1
799 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Obesity, hyperphagia, and developmental delay.



Publications
Articles associated with genes and sequences of this homology group.

TrkB expression at the neuromuscular junction is reduced during aging.
Personius KE & Parker SD. Muscle Nerve 47, 532-8 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
I-set (pfam07679)
  Immunoglobulin I-set domain.
LRR_8 (pfam13855)
  Leucine rich repeat.
LRRCT (smart00082)
  Leucine rich repeat C-terminal domain.
IG (smart00409)
  Immunoglobulin.
IG_like (smart00410)
  Immunoglobulin like.
LRRNT (cl02423)
  Leucine rich repeat N-terminal domain.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.
LRR_8 (pfam13855)
  Leucine rich repeat.
PKc_like (cl09925)
  Protein Kinases, catalytic domain.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ntrk2 includes H.sapiens NTRK2 and R.norvegicus Ntrk2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (16 transcripts, 11 species)
Actinopterygii - bony fishes (7 transcripts, 6 species)
Amphibia - amphibians (4 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)

 

 

 

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