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HomoloGene:56383. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   CACNA1A,  H.sapiens
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    NP_001120694.1
2506 aa
   CACNA1A,  P.troglodytes
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    XP_003316202.1
2377 aa
   CACNA1A,  M.mulatta
voltage-dependent P/Q-type calcium channel subunit alpha-1A-like
    XP_002801141.1
2168 aa
   CACNA1A,  C.lupus
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    XP_005632867.1
2346 aa
   CACNA1A,  B.taurus
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    NP_001068597.1
2499 aa
   Cacna1a,  M.musculus
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    NP_031604.3
2368 aa
   Cacna1a,  R.norvegicus
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    NP_037050.2
2368 aa
   cacna1a,  X.tropicalis
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
    XP_004919196.1
2388 aa
   cacna1ab,  D.rerio
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
    XP_698014.6
2393 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Episodic ataxia, type 2.
Hemiplegic migraine, familial.
Spinocerebellar ataxia-6.
Cerebellar ataxia, pure.



Publications
Articles associated with genes and sequences of this homology group.

Analysis of ischemic neuronal injury in Cav2.1 channel α1 subunit mutant mice.
Tian X, et al. Biochem Biophys Res Commun 434, 60-4 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF2967 (pfam11179)
  Protein of unknown function (DUF2967).
Ca_chan_IQ (cl07394)
  Voltage gated calcium channel IQ domain.
Ion_trans (pfam00520)
  Ion transport protein.
Ion_trans (pfam00520)
  Ion transport protein.
JCAD (pfam15351)
  Junctional protein associated with coronary artery disease.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cacna1a includes H.sapiens CACNA1A and R.norvegicus Cacna1a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (28 transcripts, 5 species)
Mammalia - mammals (16 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Hyperoartia - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (7 transcripts, 6 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 1 species)
Turbellaria - flatworms (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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