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HomoloGene:5276. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

   BRCA1,  H.sapiens
breast cancer 1, early onset
    NP_009231.2
1884 aa
   BRCA1,  P.troglodytes
breast cancer 1, early onset
    NP_001038958.1
1863 aa
   BRCA1,  M.mulatta
breast cancer 1, early onset
    NP_001108421.1
1863 aa
   BRCA1,  C.lupus
breast cancer 1, early onset
    NP_001013434.1
1878 aa
   BRCA1,  B.taurus
breast cancer 1, early onset
    NP_848668.1
1849 aa
   Brca1,  M.musculus
breast cancer 1
    NP_033894.3
1812 aa
   Brca1,  R.norvegicus
breast cancer 1, early onset
    NP_036646.1
1817 aa
   BRCA1,  G.gallus
breast cancer 1, early onset
    NP_989500.1
1749 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Breast cancer-1.
Breast-ovarian cancer.
Ovarian cancer.
Papillary serous carcinoma of the peritoneum.



Publications
Articles associated with genes and sequences of this homology group.

Identification of germline BRCA1 mutations among breast cancer families in Northeastern Iran.
Kooshyar MM, et al. Asian Pac J Cancer Prev 14, 4339-45 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
BRCT_assoc (pfam12820)
  Serine-rich domain associated with BRCT.
zf-C3HC4_2 (pfam13923)
  Zinc finger, C3HC4 type (RING finger).
BRCT (cl00038)
  Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
EIN3 (cl04813)
  Ethylene insensitive 3.
RING (cl17238)
  RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Brca1 includes H.sapiens BRCA1 and R.norvegicus Brca1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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